MDMA synthesis via NaBH4 from MDP2P

[tajira]

how can I replace hcl gas?

 

[mygodson]

how can I replace hcl gas?

tajira
You can use hydrochloric acid, then concentrate and dry under reduced pressure, and add acetonitrile or acetone for dispersion and filtration

 

[chuckmcgill]

@G.Patton Hi thanks for your work! Do you have any advice on dissolving the MDMA freebase into DCM? Ours formed an apple sauce in the dcm (it tests purple black in marque reagant). We had dessicant in the mixture (mag sulfate) and used @btcboss2022 invitro methylamine HCL method but our organic layer is not homogenous so we are wondering if there are tricks thanks!

 

[G.Patton]

@G.Patton Hi thanks for your work! Do you have any advice on dissolving the MDMA freebase into DCM? Ours formed an apple sauce in the dcm (it tests purple black in marque reagant). We had dessicant in the mixture (mag sulfate) and used @btcboss2022 invitro methylamine HCL method but our organic layer is not homogenous so we are wondering if there are tricks thanks!

chuckmcgill>>>Do you have any advice on dissolving the MDMA freebase into DCM?
What is a problem with dissolving?
>>>We had dessicant in the mixture (mag sulfate)
Have you tried suction filtration?

 

[mygodson]

Thanks, Im finding a lot of information online about mgSO4 being used as a water/oil emulsion stabilizer. I did not find this property reported for Na2SO4. I will try Sodium next time and see if I have better results, if not ill get a pic.

chuckmcgill
Both magnesium sulfate and sodium sulfate can be used, but the sodium sulfate crystal is relatively large and easy to deposit at the bottom, which is good

 

[bitcoinup2020]

Hello, I'm a newbie studying and experimenting.

I don't have a Reactor 20 L, what equipment can I use?

Thank you very much for the answer.

 

[G.Patton]

Hello, I'm a newbie studying and experimenting.

I don't have a Reactor 20 L, what equipment can I use?

Thank you very much for the answer.

bitcoinup2020Hi, you can scale down your synthesis to small flask and other equipment.

 

[bitcoinup2020]

hello
I would like to know if I can use
40%Methylamine in Methanol Solution CAS Number:74-89-5
instead of using Methylamine gas or not - in the process of mixing with Methanol

 

[G.Patton]

hello
I would like to know if I can use
40%Methylamine in Methanol Solution CAS Number:74-89-5
instead of using Methylamine gas or not - in the process of mixing with Methanol

bitcoinup2020yes, you can

 

[bitcoinup2020]

yes, you can

G.PattonThank you very much for the answer.

If I have any further questions, I will ask you again.

I will continue to sponsor this site forever.

You should have a special video forum for special members who donate to support the site as a tier or higher format. I will be able to donate to support more sites.

 

[FredDurst]

Mr G.Patton. I have noticed this is a rewrite of an old synthesis write up by Labtop on the Rhodium Archive. No problem with this, just one thing. At the start Labtop suggests that drying the imine before the imine is reduced is not necessary with MDMA due to the stability of the imine. However you have left this detail out. Is this because you say it is required to dry the Imine before reduction or no?

There is a relatively fast formation of the imine and the imine is reduced rapidly. There's no reduction of the ketone to the secondary alcohol. In similar reactions, the water that is produced during the forming of the imine (Schiff Base) is removed from the reaction before the imine is reduced with drying salt, or molecular sieves, or by using toluene as the solvent, so the water and the toluene form an azeotrope.

 

[G.Patton]

@FredDurst Hi, It isn't necessary. I omitted this information.

Because of the stability of the imine, this is not necessary for the production of MDMA. (c)

Preparation of MDMA by reductive amination with sodium borohydride

 

[bitcoinup2020]

Does this step require a reflux condenser?

 

[bitcoinup2020]

Reagents preparation
Methylamine gas (MeNH2) 300 g is dissolved in chilled 3000 g methanol (MeOH; -17-20 °C) in 20 L reactor, equipped with thermometer and overhead stirrer. The mixture is cooled down to 5 °C. The stirrer is turned on and MDP2P 1000 g is added.

Does this step require a reflux condenser?

thanks for the answer

 

[G.Patton]

Reagents preparation
Methylamine gas (MeNH2) 300 g is dissolved in chilled 3000 g methanol (MeOH; -17-20 °C) in 20 L reactor, equipped with thermometer and overhead stirrer. The mixture is cooled down to 5 °C. The stirrer is turned on and MDP2P 1000 g is added.

Does this step require a reflux condenser?

thanks for the answer

bitcoinup2020Hello, yes. It's worth to using it.

 

[bitcoinup2020]

Please help explain more information in this section.
The mixture is stirred for 2 days. The stirring time can be reduced to 4 h for people in a hurry, 10-20% will be lost.

After adding all the sodium borohydride (NaBH4), we can reduce the stirring time to 4 hours right now, can I do the next step? or must complete 48 hours

Thank you very much for the answer.

 

[G.Patton]

Please help explain more information in this section.
The mixture is stirred for 2 days. The stirring time can be reduced to 4 h for people in a hurry, 10-20% will be lost.

After adding all the sodium borohydride (NaBH4), we can reduce the stirring time to 4 hours right now, can I do the next step? or must complete 48 hours

Thank you very much for the answer.

bitcoinup2020Hello. There is clearly written that yes, you can. You will lose about 10-20% yield.

 

[bblanco]

Hello. There is clearly written that yes, you can. You will lose about 10-20% yield.

G.Pattoni scaled it to 10gr mdp2p.. haha if you know how i, as 6 week old suburban sjamaan worked to something which i made following these steps but only as 1234... i did not use stirrer, vaccum pump jadaa. in the 6 weeks destroyed my 2 bigggest rbf and when needed sep. funnel BAM ... no funnel for me anymore...
did not waited like mentioned just stirred and put some swung in it in ended up with as i would describe described kind of mdma... its a start but i want to see crystals... but.. most talk here is theoraticly... im different... as i had to know if mdma, filled a capsule like 13-14 h ago... under 200mg.. look it misses 2 aspects which i remember MDMA which i describe the yawning folllowed by the tunnel flows over in a x amounts of hours pink sunglasses vibe and just love...
that was 10 years ago.. now no yawning no real tunnel... for the rest i think higher dose and i would be 100% but at least it fucking sweet..

 

[bonotuto]

can you make a video tutorial about this method syntesis..it will help a lot all of us

 

[G.Patton]

can you make a video tutorial about this method syntesis..it will help a lot all of us

bonotutoHello, we will make such video for sure. Now, we are working with methamphetamine connected videos in our work desks. Stay tune.

 

[bblanco]

hello.. maybe stupid question.. i have everything instead of

• Methylamine gas (MeNH2) 300 g;
• Methanol (MeOH) 3000 g;

instead i have methylamine 7cas 4-89-5

 

[G.Patton]

hello.. maybe stupid question.. i have everything instead of

• Methylamine gas (MeNH2) 300 g;
• Methanol (MeOH) 3000 g;

instead i have methylamine 7cas 4-89-5

bblancoIs it alcohol or water solution of methylamine?

 

[bblanco]

Is it alcohol or water solution of methylamine?

G.Pattonin alcohol.. smells like dead fish

 

[JESSIE]

Is it alcohol or water solution of methylamine?

G.PattonAlcohol , can you directly use this or should u take an other ratio in consideration thx in advance

 

[JESSIE]

can you directly use methalymine 40% in methanol instead of disolving the gas ( should you handle other ratio)

 

[G.Patton]

can you directly use methalymine 40% in methanol instead of disolving the gas ( should you handle other ratio)

JESSIEHello, yes, you can.

 

[JESSIE]

Hello, yes, you can.

G.Pattonthanks for the contribution