P2P Synthesis From P2NP

[G.Patton]

When mixing,cooled the 20 L Round bottom flask must be closed?

primitiveintelectualNo, in opposite case reaction flask can explode with very upset consequences.

I don't know how to count it

You can pure HCl 37% acid and stir it until ph 6.5-7, if you can't count.

 

[gmo]

No, in opposite case reaction flask can explode with very upset consequences.

You can pure HCl 37% acid and stir it until ph 6.5-7, if you can't count.

G.PattonMaster, Why do we need this ph?

 

[Zhopkins05]

After adding the hydrocloric acid instead of yellow I got a bluish color what could this be attributed to?

 

[吃肉的狼]

I want to learn how to make methamphetamine and crystal meth. Is there anyone who can teach me the specific operation and production process? ! ! Thank you

 

[吃肉的狼]

Is there anyone who can teach me how to make methamphetamine and methamphetamine? The specific production process, the reaction of each step, the specific usage and dosage, and the list of reagents that need to be prepared Precautions I don’t want any unexpected situations

 

[Marvin "Popcorn" Sutton]

Is there anyone who can teach me how to make methamphetamine and methamphetamine? The specific production process, the reaction of each step, the specific usage and dosage, and the list of reagents that need to be prepared Precautions I don’t want any unexpected situations

吃肉的狼Any Expert from our forum will help you. I wrote to you in a PM.

 

[吃肉的狼]

Can mercury chloride be replaced with mercury nitrate?

 

[GhostChemist]

Can mercury chloride be replaced with mercury nitrate?

吃肉的狼Yes

 

[G.Patton]

Can mercury chloride be replaced with mercury nitrate?

吃肉的狼This topic about P2P synthesis. Ask your questions in appropriate topic. The best option is read comments before ask cuz this question has already discussed 1 million times...

 

[yuanye36547]

Is the methanol here, that is, IPA, isopropyl alcohol?

 

[GhostChemist]

Is the methanol here, that is, IPA, isopropyl alcohol?

yuanye36547You can use any type of alcohol here: MeOH, EtOH or IPA

 

[gmo]

Download Video

Phenylacetone (P2P) synthesis

• Novator
• Apr 3, 2023
• 17
• 1-phenyl-2-propanone amphetamine methamphetamine p2np p2p phenyl-2-nitropropene phenylacetone stimulant video synthesis

Phenylacetone (P2P) synthesis from P2NP.
https://bbgate.com/threads/p2p-synthesis-from-p2np.188/

Reagents:

• 1-Phenyl-2-nitropropene (P2NP; cas 705-60-2) 1000 g;
• Methanol (MeOH) 10 L;
• Sodium borohydride (NaBH4) 470 g;
• Hydrogen peroxide (H2O2) 30% 6 L;
• Potassium carbonate (K2CO3) 1800 g;
• Hydrochloric acid (HCl) 37% aq;
• Dichloromethane (CH2CI2) 5 L;
• Sodium hydroxide (NaOH) 5 L 25% aq;
• Distilled water (H2O) 5 L;

Equipment and glassware:

• 20 L Round bottom flask;
• Water bath, ice;
• HCl gas source;
• Magnetic or top stirrer;
• Retort stand and clamp for securing apparatus;
• Vacuum source;
• Glass rod and spatula;
• Rotovap machine;
• pH indicator paper;
• Laboratory scale (1-1000 g is suitable);
• Measuring cylinders 1000 mL;
• 1000 mL x3; 2000 mL x3; 5000 mL x3 Beakers;
• Several buckets;

Reaction scheme:

View attachment 1384 ​

Synthesis:

1. 1-Phenyl-2-nitropropene 1000 g is dissolved by methanol (MeOH) 10 L in 20 L flask.
2. The reaction mixture is cooled to 0 °C by an ice/salt bath with good stirring.
3. Sodium borohydride (NaBH4) 470 g is added to reaction mixture in small portions with a constant stirring in order to control reaction temperature below 15 °C.
4. The ice/salt bath is removed after an exothermic reaction end.
5. The solution is stirred at room temperature for 2 h.
6. Then, the solution is cooled to 0 °C in ice/salt bath again.
7. Hydrogen peroxide (H2O2) 30% 6 L and potassium carbonate (K2CO3) 1800 g are added into the reaction flask.
8. The solution is stirred for 24 h at room temperature.
9. Next, hydrochloric acid (HCl) 37% aq is poured into the mixture dropwise to reach pH 6.5-7. The reaction is exothermic, CO2 is released (caution!).
10. The mixture is extracted with dichloromethane (CH2CI2) 5 L, extract is washed with sodium hydroxide (NaOH) 5 L 25% aq. and distilled water (H2O) 5 L.
11. Dichloromethane (CH2CI2) is distilled off under vacuum to give a clear phenylacetone (P2P, cas 103-79-7) yellow oil. The yield is 70%.​

GhostChemist

Download Video

Phenylacetone (P2P) synthesis

• Novator
• Apr 3, 2023
• 17
• 1-phenyl-2-propanone amphetamine methamphetamine p2np p2p phenyl-2-nitropropene phenylacetone stimulant video synthesis

Phenylacetone (P2P) synthesis from P2NP.
https://bbgate.com/threads/p2p-synthesis-from-p2np.188/

Reagents:

• 1-Phenyl-2-nitropropene (P2NP; cas 705-60-2) 1000 g;
• Methanol (MeOH) 10 L;
• Sodium borohydride (NaBH4) 470 g;
• Hydrogen peroxide (H2O2) 30% 6 L;
• Potassium carbonate (K2CO3) 1800 g;
• Hydrochloric acid (HCl) 37% aq;
• Dichloromethane (CH2CI2) 5 L;
• Sodium hydroxide (NaOH) 5 L 25% aq;
• Distilled water (H2O) 5 L;

Equipment and glassware:

• 20 L Round bottom flask;
• Water bath, ice;
• HCl gas source;
• Magnetic or top stirrer;
• Retort stand and clamp for securing apparatus;
• Vacuum source;
• Glass rod and spatula;
• Rotovap machine;
• pH indicator paper;
• Laboratory scale (1-1000 g is suitable);
• Measuring cylinders 1000 mL;
• 1000 mL x3; 2000 mL x3; 5000 mL x3 Beakers;
• Several buckets;

Reaction scheme:

View attachment 1384 ​

Synthesis:

1. 1-Phenyl-2-nitropropene 1000 g is dissolved by methanol (MeOH) 10 L in 20 L flask.
2. The reaction mixture is cooled to 0 °C by an ice/salt bath with good stirring.
3. Sodium borohydride (NaBH4) 470 g is added to reaction mixture in small portions with a constant stirring in order to control reaction temperature below 15 °C.
4. The ice/salt bath is removed after an exothermic reaction end.
5. The solution is stirred at room temperature for 2 h.
6. Then, the solution is cooled to 0 °C in ice/salt bath again.
7. Hydrogen peroxide (H2O2) 30% 6 L and potassium carbonate (K2CO3) 1800 g are added into the reaction flask.
8. The solution is stirred for 24 h at room temperature.
9. Next, hydrochloric acid (HCl) 37% aq is poured into the mixture dropwise to reach pH 6.5-7. The reaction is exothermic, CO2 is released (caution!).
10. The mixture is extracted with dichloromethane (CH2CI2) 5 L, extract is washed with sodium hydroxide (NaOH) 5 L 25% aq. and distilled water (H2O) 5 L.
11. Dichloromethane (CH2CI2) is distilled off under vacuum to give a clear phenylacetone (P2P, cas 103-79-7) yellow oil. The yield is 70%.​

Can I use chloroform for extraction?

 

[GhostChemist]

Can I use chloroform for extraction?

gmoYep
You can use the chloroform as extragent

 

[G.Patton]

Can I use chloroform for extraction?

gmoHello, I think yes.

 

[wael gano]

Borehydride is not available in my country currently
I now have tin chloride and ethyl acetate. How do I arrange the steps? I need advice from someone who tried reducing p2np using tin chloride.

 

[NAGAINAGAYOSHI]

What can be used instead of dcm?

 

[WillD]

What can be used instead of dcm?

NAGAINAGAYOSHItoluene, benzene, ether, xylene, etc...

 

[virus0815]

can i use anhydrous dichlormethane?